Effects of Benzene Exposure on Animals
A number of animal studies have demonstrated that benzene exposure can induce bone marrow damage, changes in circulating blood cells, developmental and reproductive effects, alterations of the immune response, and cancer.With respect to chronic toxicity, hematological changes appear to be the most sensitive indicator.
The NTP (1986) conducted a bioassay in F344 rats and B6C3F1 mice of benzene by corn oil gavage.Doses were 0, 25, 50, and 100 mg/kg-day for females and 0, 50, 100, and 200 mg/kgday for males.Dose-related lymphocytopenia and leukocytopenia were observed in both species in all dosed groups but not controls.
Mice exhibited lymphoid depletion of the thymus and spleen and hyperplasia of the bone marrow.
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see also:
Effects of Animal Exposure to Benzene
Effects of Benzene Exposure on Animals - Learn MoreLearn more about the Effects of Benzene Exposure on animals
Genetics - Reaction to Benzene
Do Genetics Effect Reaction to Benzene ExposureBenzene could be harmful to you, without you knowing! - Learn More
Exposure to Benzene
Sources and Potential Exposure to BenzeneWant to know if you are exposed to Benzene - Learn More


