Bextra Side Effects: Coronary Heart Disease-
Information provided by Bextra Attorneys

Recently, Bextra has been found to cause Coronary Heart Disease. Coronary Heart Disease is also called Coronary Artery Disease and is the condition in which arteries are narrowed and decreases the amount of necessary blood and oxygen to the heart. This can lead to an angina, ischemia, or heart attack.

Non-steroidal anti-inflammatory drugs (NSAIDs) are prescribed to patients who suffer from arthritis and pain where the most dominant adverse side effect is gastrointestinal toxicity.

NSAIDs work by blocking both COX-1 (maintains homeostasis in the stomach, kidney, and GI tract) and COX-2 (pain and inflammation) enzymes.

The degree to which each enzyme is blocked depends on the chemical composition of each NSAID. The most often occurring adverse effect from these non-selective NSAIDs occurs within a patient’s gastrointestinal tract.

COX-2 selective NSAIDs are believed to have an improved overall safety profile because it is hypothesized that they only target COX-2 enzymes for greater efficiency in managing patient inflammation and pain.

However, concerns have been raised about the increased risk of cardiovascular side effects (i.e. heart attack and stroke).

The VIGOR (Vioxx GI Clinical outcomes Research) study showed serious cardiovascular adverse events may occur as soon as 4 months after chronic use.

Weitz & Luxenberg is no longer accepting Bextra cases.

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