Prostate Cancer: Treatment
Cancer can be caused by many sources including smoking, genetics, and environmental hazards. Cancer caused by the environment is usually the result of industrial pollution or dumping. Improperly stored hazardous materials can leach chemicals into the soil when wet. Eventually the leaching chemicals may reach the water table and contaminate the groundwater. The National Cancer Institute (NCI) estimates that the incidence of cancer could be reduced by as much as 80-90 percent if environmental causes such as diet, tobacco, and alcohol, as well as radiation, infectious agents, and substances in the air, water, and soil were addressed. You can learn more about Prostate Cancer here, with topics such as Symptoms, Diagnosis, Staging, Treatment, and more, by selecting from the list above.
If you've been diagnosed with a cancer caused by an industrial pollutant or hazardous material, or you were misdiagnosed by a doctor or oncologist, you are not alone in your struggle. A cancer lawyer may be able to file a lawsuit and get compensation for your pain and suffering, make sure your family is provided for, and help ensure that no one else in your community is exposed to dangerous carcinogens. A cancer attorney can advocate for you with diligence and compassion, taking the worry of litigation off of your shoulders. To get your free case evaluation, fill out this simple form. Your case will be evaluated within 24 hours. If you want to help a friend who needs a cancer attorney, please click here.
Getting a Second Opinion
Many men with prostate cancer want to take an active part in making decisions about their care. It is natural to want to learn all you can about prostate cancer and your treatment choices. However, shock and stress after the diagnosis can make it hard to think of everything you want to ask your doctor. It often helps to make a list of questions before an appointment.
To help remember what the doctor says, you may take notes or ask whether you may use a tape recorder. You may also want to have a family member or friend with you when you talk to the doctor - to take part in the discussion, to take notes, or just to listen.
You do not need to ask all your questions at once. You will have other chances to ask your doctor or nurse to explain things that are not clear and to ask for more details.
Your doctor may refer you to a specialist, or you may ask for a referral. Specialists who treat prostate cancer include urologists, urologic oncologists, medical oncologists, and radiation oncologists.
Before starting treatment, you might want a second opinion about your diagnosis and treatment plan. Many insurance companies cover a second opinion if you or your doctor requests it. It may take some time and effort to gather medical records and arrange to see another doctor. Usually it is not a problem to take several weeks to get a second opinion. In most cases, the delay in starting treatment will not make treatment less effective. To make sure, you should discuss this delay with your doctor. Some men with prostate cancer need treatment right away.
There are a number of ways to find a doctor for a second opinion:
Your doctor may refer you to one or more specialists. At cancer centers,
several specialists often work together as a team.
• NCI's Cancer Information Service, at 1-800-4-CANCER, can tell you about nearby treatment centers. Information Specialists also can provide online assistance through LiveHelp at http://www.cancer.gov/cis.
• A local or state medical society, a nearby hospital, or a medical school can usually provide the names of specialists.
• The American Board of Medical Specialties (ABMS) has a list of doctors who have had training and passed exams in their specialty. You can find this list in the Official ABMS Directory of Board Certified Medical Specialists. This Directory is in most public libraries. Also, ABMS offers this information at http://www.abms.org. (Click on "Who's Certified.")
• NCI provides a helpful fact sheet called "How To Find a Doctor or Treatment Facility If You Have Cancer."
Men with prostate cancer have many treatment options. The treatment that is best for one man may not be best for another.
Treatment may involve surgery, radiation therapy, or hormone therapy. You may have a combination of treatments. If your doctor recommends watchful waiting, your health will be monitored closely. You will have treatment only if symptoms occur or get worse.
Cancer treatment is either local therapy or systemic therapy:
Local therapy: Surgery and radiation therapy are local treatments. They
remove or destroy cancer in the prostate. When prostate cancer has spread to
other parts of the body, local therapy may be used to control the disease in
those specific areas.
• Systemic therapy: Hormone therapy is systemic therapy. Hormones are given to control cancer that has spread.
The treatment that is right for you depends on the stage of the cancer, the grade of the tumor, your symptoms, and your general health. Your doctor will describe your treatment choices and the expected results.
Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects depend mainly on the type and extent of the treatment. Side effects may not be the same for each man, and they may change from one treatment session to the next. NCI's booklet Know Your Options: Understanding Treatment Choices for Prostate Cancer can tell you more about treatments and their side effects.
You should consider both the expected benefits and possible side effects of each treatment option. You may want to discuss with your doctor the possible effects on sexual activity. You can work with your doctor to create a treatment plan that reflects your medical needs and personal values.
At any stage of disease, supportive care is available to control pain and other symptoms, to relieve the side effects of treatment, and to ease emotional concerns. Information about such care is available on NCI's Web site at http://www.cancer.gov/cancertopics/coping and from Information Specialists at 1-800-4-CANCER or LiveHelp.
You may want to talk to your doctor about taking part in a clinical trial, a research study of new treatment methods. The section on "The Promise of Cancer Research" has more information about clinical trials.
You may want to ask your doctor these questions before your treatment begins:
What is the stage of the disease? Do any lymph nodes show signs of cancer? Has
the cancer spread?
Surgery is a common treatment for early stage prostate cancer. Your doctor may remove the whole prostate or only part of it. In some cases, your doctor can use a method known as nerve-sparing surgery. This type of surgery may save the nerves that control erection. But if you have a large tumor or a tumor that is very close to the nerves, you may not be able to have this surgery.
Each type of surgery has benefits and risks. Your doctor can further describe these types:
Radical retropubic prostatectomy: The
doctor removes the entire prostate and nearby lymph nodes through an
incision (cut) in the abdomen.
• Radical perineal prostatectomy: The doctor removes the entire prostate through a cut between the scrotum and the anus. Nearby lymph nodes may be removed through a separate cut in the abdomen.
• Laparoscopic prostatectomy: The doctor removes the entire prostate and nearby lymph nodes through small incisions, rather than a single long cut in the abdomen. A thin, lighted tube (a laparoscope) is used to help remove the prostate.
• Transurethral resection of the prostate (TURP): The doctor removes part of the prostate with a long, thin device that is inserted through the urethra. The cancer is cut from the prostate. TURP may not remove all of the cancer. But it can remove tissue that blocks the flow of urine.
• Cryosurgery: This type of surgery for prostate cancer is under study at some medical centers. (More about cryosurgery is in "The Promise of Cancer Research" section.)
• Pelvic lymphadenectomy: This is routinely done during prostatectomy. The doctor removes lymph nodes in the pelvis to see if cancer has spread to them. If there are cancer cells in the lymph nodes, the disease may have spread to other parts of the body. In this case, the doctor may suggest other types of treatment.
The time it takes to heal after surgery is different for each man and depends on the type of surgery he has had. You may be uncomfortable for the first few days. However, medicine can help control the pain. Before surgery, you should discuss the plan for pain relief with your doctor or nurse. After surgery, your doctor can adjust the plan if you need more pain relief.
After surgery, the urethra needs time to heal. You will have a catheter. A catheter is a tube put through the urethra into the bladder to drain urine. You will have the catheter for 5 days to 3 weeks. Your nurse or doctor will show you how to care for it.
Surgery may cause short-term problems, such as incontinence. After surgery, some men may lose control of the flow of urine (urinary incontinence). Most men regain bladder control after a few weeks.
Some men may become impotent. Nerve-sparing surgery is an attempt to avoid the problem of impotence. If a man can have nerve-sparing surgery and the operation is a success, impotence may not last. In some cases, men become permanently impotent. You can talk with your doctor about medicine and other ways to help manage the sexual effects of cancer treatment.
If your prostate is removed, you will no longer produce semen. You will have dry orgasms. If you wish to father children, you may consider sperm banking or a sperm retrieval procedure.
You may want to ask your doctor these questions before choosing surgery:
What kinds of surgery can I consider? Is nerve-sparing surgery an option for
me? Which operation do you recommend for me? Why?
Radiation therapy (also called radiotherapy) uses high-energy rays to kill cancer cells. It affects cells only in the treated area.
For early stage prostate cancer, radiation treatment may be used instead of surgery. It also may be used after surgery to destroy any cancer cells that remain in the area. In later stages of prostate cancer, radiation treatment may be used to help relieve pain.
Doctors use two types of radiation therapy to treat prostate cancer. Some men receive both types:
External radiation: The radiation
comes from a large machine outside the body. Men go to a hospital or clinic for
treatment. Treatments are usually 5 days a week for several weeks. Many men
3-dimensional conformal radiation therapy.
This type of treatment more closely targets the cancer. It spares healthy
• Internal radiation (implant radiation or brachytherapy): The radiation comes from radioactive material usually contained in small seeds. The seeds are put into the tissue. They give off radiation for months. The seeds are harmless and do not need to be removed.
Side effects depend mainly on the dose and type of radiation. You are likely to be very tired during radiation therapy, especially in the later weeks of treatment. Resting is important, but doctors usually advise patients to try to stay as active as they can.
If you have external radiation, you may have diarrhea or frequent and uncomfortable urination. Some men have lasting bowel or urinary problems. Your skin in the treated area may become red, dry, and tender. You may lose hair in the treated area. The hair may not grow back.
Internal radiation treatment may cause incontinence. This side effect usually goes away. Lasting side effects from internal radiation are not common.
Both internal and external radiation can cause impotence. Internal radiation is less likely to have this effect.
You may want to ask your doctor these questions before choosing radiation
How will radiation be given?
Hormone therapy keeps prostate cancer cells from getting the male hormones (androgens) they need to grow. The testicles are the body's main source of the male hormone testosterone. The adrenal gland makes a small amount of testosterone.
Hormone treatment uses drugs or surgery:
• Drugs: Your doctor may suggest a drug that can block natural hormones.
Luteinizing hormone-releasing hormone (LH-RH)
agonists: These drugs can prevent
the testicles from making testosterone. Examples are
• Antiandrogens: These drugs can block the action of male hormones. Examples are flutamide, bicalutamide, and nilutamide.
• Other drugs: Some drugs can prevent the adrenal gland from making testosterone. Examples are ketoconazole and aminoglutethimide.
• Surgery: Surgery to remove the testicles is called orchiectomy.
After orchiectomy or treatment with an LH-RH agonist, your body no longer gets testosterone from the testicles. However, the adrenal gland still produces a small amount of male hormones. You may receive an antiandrogen to block the action of the male hormones that remain. This combination of treatments is known as total androgen blockade. Studies have not shown whether total androgen blockade is more effective than surgery or an LH-RH agonist alone.
Doctors can usually control prostate cancer that has spread to other parts of the body with hormone therapy. The cancer often does not grow for several years. But in time, most prostate cancers can grow with very little or no male hormones. Hormone therapy is no longer helpful. At that time, your doctor may suggest other forms of treatment that are under study.
Hormone therapy is likely to affect your quality of life. It often causes side effects such as impotence, hot flashes, loss of sexual desire, and weaker bones. An LH-RH agonist may make your symptoms worse for a short time when you first take it. This temporary problem is called "flare." The treatment gradually causes your testosterone level to fall. Without testosterone, tumor growth slows. Your condition may improve. (To prevent flare, your doctor may give you an antiandrogen for a while along with the LH-RH agonist.)
Antiandrogens (such as nilutamide) can cause nausea, diarrhea, or breast growth or tenderness. Rarely, they may cause liver problems (pain in the abdomen, yellow eyes, or dark urine). Some men who use nilutamide may have difficulty breathing. Some may have trouble adjusting to sudden changes in light.
If used for a long time, ketoconazole may cause liver problems, and aminoglutethimide can cause skin rashes. If you receive total androgen blockade, you may have more side effects than if you have just one type of hormone treatment.
Any treatment that lowers hormone levels can weaken your bones. Your doctor can suggest medicines or dietary supplements that can reduce your risk of bone fractures.
You may want to ask your doctor these questions before choosing hormone
What kind of hormone therapy will I have? Would you recommend drugs or surgery?
You may choose watchful waiting if the risks and possible side effects of treatment outweigh the possible benefits. Your doctor may offer this choice if you are older or have other serious health problems. Your doctor may also suggest watchful waiting if you are diagnosed with early stage prostate cancer that seems to be slowly growing. Your doctor will offer you treatment if symptoms occur or get worse.
Watchful waiting avoids or delays the side effects of surgery and radiation, but this choice has risks. It may reduce the chance to control cancer before it spreads. Also, it may be harder to cope with surgery and radiation therapy as you age.
You may decide against watchful waiting if you do not want to live with an untreated cancer. If you choose watchful waiting but grow concerned later, you should discuss your feelings with your doctor. A different approach is nearly always available.
Watchful waiting is under study. See "The Promise of Cancer Research" for information about this study.
You may want to ask your doctor these questions before choosing watchful
If I choose watchful waiting, can I change my mind later on?
Source: National Cancer Institute www.cancer.gov
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