Celebrex Users Should Know About Proper Dosage
Courtesty of the FDA
The following is information regarding the Dosage and Administration for
Celebrex:
Carefully consider the potential benefits and risks of
CELEBREX and other treatment options before deciding to use CELEBREX. Use the
lowest effective dose for the shortest duration consistent with individual
patient treatment goals.
For osteoarthritis and rheumatoid arthritis, the
lowest dose of CELEBREX should be sought for each patient. These doses can be
given without regard to timing of meals.
Osteoarthritis: For
relief of the signs and symptoms of osteoarthritis the recommended oral dose is
200 mg per day administered as a single dose or as 100 mg twice per day.
Rheumatoid arthritis: For relief of the signs and symptoms of
rheumatoid arthritis the recommended oral dose is 100 to 200 mg twice per
day.
Juvenile Rheumatoid Arthritis: Pediatric Patients (2 years
and older) Dose
=10 kg to =25 kg 50 mg capsule twice daily
>25 kg 100
mg capsule twice daily
Method of Administration
For patients
who have difficulty swallowing capsules, the contents of a CELEBREX capsule can
be added to applesauce. The entire capsule contents are carefully emptied onto a
level teaspoon of cool or room temperature applesauce and ingested immediately
with water. The sprinkled capsule contents on applesauce are stable for up to 6
hours under refrigerated conditions (2-8° C/ 35-45° F).
Ankylosing
Spondylitis (AS): For the management of the signs and symptoms of AS, the
recommended dose of CELEBREX is 200 mg daily single (once per day) or divided
(twice per day) doses. If no effect is observed after 6 weeks, a trial of 400 mg
daily may be worthwhile. If no effect is observed after 6 weeks on 400 mg daily,
a response is not likely and consideration should be given to alternate
treatment options.
Management of Acute Pain and Treatment of Primary
Dysmenorrhea: The recommended dose of CELEBREX is 400 mg initially, followed
by an additional 200 mg dose if needed on the first day. On subsequent days, the
recommended dose is 200 mg twice daily as needed.
Familial adenomatous
polyposis (FAP): Usual medical care for FAP patients should be continued
while on CELEBREX. To reduce the number of adenomatous colorectal polyps in
patients with FAP, the recommended oral dose is 400 mg twice per day to be taken
with food.
Special Populations
Hepatic
insufficiency: The daily recommended dose of CELEBREX capsules in patients
with moderate hepatic impairment (Child-Pugh Class B) should be reduced by
approximately 50%. The use of CELEBREX in patients with severe hepatic
impairment is not recommended.
Weitz & Luxenberg is no longer accepting Celebrex cases.
see also:
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