Celebrex Side Effects: Coronary Heart Disease
Coronary Heart Disease is also called Coronary Artery Disease and is a
condition in which arteries are narrowed and this decreases the amount of
necessary blood and oxygen to the heart.
This can lead to an angina, ischemia, or heart attack.
Non-steroidal anti-inflammatory drugs (NSAIDs) are prescribed to patients who
suffer from arthritis and pain where the most dominant adverse side effect is
gastrointestinal toxicity.
NSAIDs work by blocking both COX-1 (maintains
homeostasis in the stomach, kidney, and GI tract) and COX-2 (pain and
inflammation) enzymes.
The degree to which each enzyme is blocked depends
on the chemical composition of each NSAID.
The most often occurring
adverse effect from these non-selective NSAIDs occurs within a patient’s
gastrointestinal tract.
COX-2 selective NSAIDs are believed to have an improved overall safety
profile because it is hypothesized that they only target COX-2 enzymes for
greater efficiency in managing patient inflammation and pain.
However,
concerns have been raised about the increased risk of cardiovascular side
effects (i.e. heart attack and stroke).
The VIGOR (Vioxx GI Clinical
outcomes Research) study showed serious cardiovascular adverse events may occur
as soon as 4 months after chronic use.
If you or a loved one is experiencing some signs of heart disease related to Celebrex please fill out the following simple form, or call toll free (800) 476-6070, e-mail us at ClientRelations@weitzlux.com for a FREE lawsuit consultation.
Weitz & Luxenberg is no longer accepting Celebrex cases.
see also:
Sudden Cardiac Death
Celebrex Side Effects: Sudden Cardiac Death (SCD)Celebrex Side Effects: Sudden Cardiac Death Information
Angina
Celebrex Side Effects: AnginaCelebrex Side Effects - Angina Information
Heart Risks
Learn more about the dangerous heart risks of CelebrexHeart Risks double while taking Celebrex - Find out more
