Problems with Celebrex - Archived Articles

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Barton, Dingell Ask Pfizer For Documents Related to Celebrex

(energycommerce.house.gov) - December 17, 2004

U.S. Rep. Joe Barton, R-Texas, chairman of the House Energy and Commerce Committee, and U.S. Rep. John Dingell, D-Mich., ranking member of the House Energy and Commerce Committee, today sent the following letter to Hank McKinnell, chairman and CEO of Pfizer Inc.:

Dear Dr. McKinnell: As part of its continuing oversight of the public health and the safety of prescription drugs, the Committee is examining potential cardiovascular safety issues surrounding COX-2 inhibitor drugs, such as Vioxx, Celebrex, and Bextra. As you know, Merck & Co., Inc. (“Merck”) recently withdrew its COX-2 inhibitor drug rofecoxib, known commercially as Vioxx, from the market due to an increased risk profile associated with cardiovascular safety. As part of our investigation to date, we requested documents from the Food & Drug Administration (“FDA”) relating to cardiovascular safety concerns associated with Celebrex and Bextra, two Cox-2 inhibitor drugs manufactured and marketed by Pfizer, Inc. (“Pfizer”), in addition to Vioxx. We have learned today that Pfizer Inc. (“Pfizer”) announced prior to the stock market opening that it received results last night from a U.S. National Cancer Institute (“NCI”) study that showed patients taking Celebrex had a 2.5 fold increase in their risk of a serious cardiovascular adverse event compared to those patients taking a placebo.

Product Licensing; Canadian health officials say too early to issue warning on Pfizer's Celebrex

Heart Disease Weekly, GA - Nov 28, 2004

Canada Adverse Drug Reaction Monitoring Program, part of the federal health department Health Canada, has collected 100 adverse- reaction reports on Celebrex over the past 5 years. Those include 19 cases of heart attack, cardiac arrest or heart failure, five strokes and included 14 deaths. Complaints are submitted to the agency directly by health professionals and consumers, and its database is meant to serve as a sort of early warning system for safety problems.

Use of drug etodolac instead of drugs like Celebrex or Bextra could save $40 million annually

News-Medical in Pharmaceutical News, World - Nov 28, 2004

"Since etodolac is available as a generic medicine, as much as an 80 percent cost savings can be achieved if patients were to use it rather than branded medications such as Celebrex or Bextra," said Dr. Byron Cryer, associate professor of internal medicine at UT Southwestern, a VA physician and senior author of the study published in the November issue of Gastroenterology. "In the 13 years of etodolac's use in the United States, there have been no reports of increases in cardiovascular events associated with this drug either." Etodolac is a non-steroidal anti-inflammatory drug (NSAID) in the same class as Celebrex. It was first released in the United States in 1991 as a pain reliever and arthritis treatment but has since gone off patent and is generically available.

Pfizer halts Celebrex sales in Turkey in dispute over warning label

San Diego Union Tribune, CA - Nov 24, 2004 

Pfizer Inc. said Wednesday it has temporarily halted sales of its pain reliever Celebrex in Turkey because health authorities there sought to include very restrictive language concerning cardiovascular issues on its label.

Safety of Entire Family of Painkillers Questioned

The Atlanta Journal-Constitution, GA - Nov 24, 2004

"We don't know that any of the cox-2 inhibitors are perfectly safe," said Dr. Eric Topol, chairman of cardiovascular medicine and chief academic officer of the Cleveland Clinic, who was one of the first to speak out about possible problems. "Two out of three are already signed on as being problematic. One has been withdrawn [Vioxx], one is probably getting a black box [Bextra], and Celebrex may be a small hazard, but we just don't know."

NSAIDs Don't Relieve Knee Pain

Ivanhoe Newswire - Nov 24, 2004

Popping over-the-counter non-steroidal anti-inflammatory pills, such as aspirin, Motrin or prescription drugs like Celebrex, won’t do much to relieve knee pain associated with osteoarthritis, report investigators who analyzed the results of 23 studies comparing the drugs to placebos.

Weitz & Luxenberg is no longer accepting Celebrex cases.

see also:

Generic Generic drugmaker Teva blocked from launching copycat Celebrex
Legal Battles Over Generic Celebrex

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