Crestor Side Effects
Crestor is an effective treatment used to lower cholesterol, but it has been
linked to dangerous side effects like rhabdomyolysis and kidney damage. You are
twice as likely to develop these side effects using Crestor than with other
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Some doctors have been hesitant to prescribe rosuvastatin because of concerns that this agent might have a higher incidence of rhabdomyolysis (a severe undesired side effect) than other statins; this negative impact on sales performance has been much more pronounced in the United States than in other countries.
The FDA has indicated that "it does not appear that the risk [of rhabdomyolysis] is greater with Crestor than with other marketed statins", but has mandated that a warning about this side effect, as well as a kidney toxicity warning, be added to the product label.
Regarding kidney function effects, recent reviews of published trial data, focusing on renal function, on placebo vs. statin, and tracking renal function over time have shown a small but distinct effect of statins to lessen renal dysfunction, when added to treatment (compared to placebo), and to slow the progression of further renal function decline over time.
All the statins have a somewhat dose related response to increase urine protein levels, rosuvastatin the strongest association.
Because increased urine protein has long been relied upon as a warning sign of renal glomerular dysfunction, this increase on statin treatment had been feared to indicate a negative effect on renal function.
However, all current evidence is that the increase in urinary protein is from the renal tubular cells, not the glomeruli, and is due to cholesterol synthesis inhibition the tubular cells but is not associated with any decline in renal function.