Malpractice News: FDA Approves Xenazine for Huntington’s Disease

Malpractice News: On August 15, 2008, the Food and Drug Administration (FDA) announced it had approved the drug Xenazine for the treatment of Huntington’s Disease, a rare inherited disease that causes uncontrolled movements and the deterioration of mental abilities. The disease affects about 30,000 patients in the United States.

Xenazine is not meant to cure Huntington’s, but to treat Chorea, the jerky, involuntary movements that Huntington’s patients experience. The drug works by reducing the amount of dopamine, which communicates signals between the body’s nerve cells to trigger muscle movements. In Huntington’s patients, the system is overactive and triggers involuntary movements.

The drug has some known side effects, which include depression, suicidal thoughts and actions. Since Huntington’s patients often suffer from depression issues because of their condition, the FDA has required a special risk management program to monitor Huntington’s patients for worsening psychiatric symptoms.

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