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Mesothelioma Publication - Pemetrexed in Malignant Pleural Mesothelioma

This is an abstract of an article about Pemetrexed in the treatment of malignant pleural mesothelioma published at PubMed by the NIH.

Pemetrexed in malignant pleural mesothelioma.

Gatzemeier U.
Department of Thoracic Oncology, Hospital Grosshansdorf, Grosshansdorf, Germany.
Oncology (Huntingt). 2004 Nov;18(13 Suppl 8):26-31.

Malignant pleural mesothelioma (MPM) is a disease with a poor prognosis, related in part to the aggressiveness of this disease, and in part due to the lack of drugs that have demonstrated tumor activity.

Historically, antifolates such as methotrexate have been the most active drugs in the treatment of mesothelioma. Newer antifolates have recently demonstrated higher efficacy than older regimens in the treatment of this rare disease.

One of these agents, pemetrexed (Alimta), has been evaluated both as a single agent and as part of a combination regimen. Pemetrexed has been studied in three trials in patients with MPM, and two phase I trials included patients with MPM.

In a phase II trial, pemetrexed was studied as a single agent in patients with MPM. Seven of 64 patients achieved partial responses, with a median overall survival of 10.7 months. A large, randomized, phase III trial was conducted to compare pemetrexed/cisplatin with cisplatin.

The response rate was 41.3% compared with 16.7%, median survival was 12.1 months compared with 9.3 months, and 1-year survival was 50.3% vs 38% in the pemetrexed/cisplatin and cisplatin arms, respectively. The combination of pemetrexed/cisplatin also demonstrated superiority in quality of life and pulmonary functioning analysis when compared with cisplatin.

Exposure to asbestos is known to cause serious illnesses such as mesothelioma, asbestos-related lung cancer or asbestosis.

If you or a loved one has been diagnosed with an asbestos illness, contact our lawyers today for a free review of your case. A Weitz & Luxenberg representative will contact you as soon as possible.

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see also:

Vinorelbine and Oxaliplatin Mesothelioma Publication - Vinorelbine and Oxaliplatin
Know about Mesothelioma and Vinorelbine and Oxaliplatin

Intraoperative Radiation Therapy Mesothelioma Cancer Publication - Intraoperative Radiation Therapy
Info from our mesothelioma lawyers: Intraoperative Radiation Therapy

National Mesothelioma Publications The National Institute of Health mesothelioma research publications
Mesothelioma publications from the National Institute of Health