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Clinical Trials for Mesothelioma Patients: Dasatinib (NSC #732517)

Read about a current clinical trial being conducted to study the effects of Dasatinib (NSC #732517) for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma

A Phase II Study of Dasatinib (NSC #732517) in Patients With Previously Treated Malignant Mesothelioma

Brief Summary

RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
PURPOSE: This phase II trial is studying how well Dasatinib works in treating patients with previously treated malignant mesothelioma.

Detailed Description and Objectives
Primary:
• To determine the rate of progression-free survival (PFS) at 24 weeks (or 5.5 months) in patients with malignant mesothelioma treated with Dasatinib.
Secondary
• To determine the response rate (partial response [PR] and complete response [CR]) in patients with malignant mesothelioma treated with Dasatinib.
• To determine the response duration in patients with malignant mesothelioma treated with Dasatinib.
• To describe the overall survival (OS) of patients with malignant mesothelioma treated with Dasatinib.
• To describe the toxicity profile of Dasatinib in patients with malignant mesothelioma.
• To determine whether the amount of expression of EphA2 and PDGFRß, as measured by immunohistochemistry from tumor specimens, correlates with PFS in patients with malignant mesothelioma.
• To determine whether plasma levels of VEGF and PDGFRß, serum levels of CSF-1, and soluble mesothelin-related protein correlate with PFS in patients with malignant mesothelioma.
• To determine whether inhibition of Src phosphorylation in PBMC correlates with PFS.
• To assess inhibition of phosphorylation of Src, EphA2, and PDGFRß in tumor tissue by Dasatinib.

Courtesy of ClinicalTrials.gov,

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