Clinical Trials for Mesothelioma Patients: Cisplatin, Imatinib Mesylate, and Pemetrexed Outcomes Measures

Read about the outcomes measures for a current clinical trial being conducted to study the effects of Cisplatin, Imatinib Mesylate, and Pemetrexed or patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only. At this time, this study is only being conducted in Lille, France.

Primary Outcome Measures:
• Determine the maximum tolerated dose of the combination of cisplatin, imatinib mesylate, and pemetrexed. [ Time Frame: 2 Years ] [ Designated as safety issue: No ] Secondary Outcome Measures:

• Explore the biologic effects of cisplatin, imatinib mesylate, and pemetrexed on tumor tissue by histologic analysis of biopsy tissue. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Explore the biologic effects of cisplatin, imatinib mesylate, and pemetrexed on tumor tissue by non-invasive assessments of tumor vascularity. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Explore the biologic effects of cisplatin, imatinib mesylate, and pemetrexed on tumor tissue by electron microscopy analysis of endothelial cell architecture. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Explore the effects of cisplatin, imatinib mesylate, and pemetrexed on surrogate markers in serum. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Assess the rate of response to therapy. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Determine the doses of the combination regimen of cisplatin, imatinib mesylate, and pemetrexed that enables de-phosphorylation of PDGF-R on malignant mesothelioma tumor cells. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

• Determine the pharmacokinetic interaction between agents in this combination regimen. [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

Courtesy of ClinicalTrials.gov, a service of the U.S. National Institutes of Health

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