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Clinical Trials for Mesothelioma Patients: Dasatinib (NSC #732517) Patient Characteristics

Read the patient characteristics for a current clinical trial being conducted to study the effects of Dasatinib (NSC #732517) for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Patient Characteristics:
ECOG performance status 0-1
Granulocytes = 1,500/µL
Platelet count = 100,000/µL
Total bilirubin = 2 x upper limit of normal (ULN)
AST (SGOT) = 2.5 x ULN
Creatinine clearance = 60 mL/min
INR < 1.5
PTT < 40 seconds
QTc < 450 msec
Not pregnant or nursing
Fertile patients must use effective contraception
No significant cardiac disease, including any of the following:
o New York Heart Association (NYHA) class III-IV congestive heart failure (CHF)
o Unstable angina
o Myocardial infarction or ventricular tachyarrhythmia within 6 months of study entry
o Ejection fraction less than institutional normal (in patients with a history of CHF or currently with NYHA class I or II CHF)
o Prolonged QTc > 450 msec (Fridericia correction)
o Major conduction abnormality, unless a cardiac pacemaker is present
o Hypokalemia or hypomagnesemia that cannot be corrected
No history of significant bleeding disorder unrelated to cancer, including any of the following:
o Congenital bleeding disorder (e.g., von Willebrand disease)
o Acquired bleeding disorder within the past year (e.g., acquired anti-factor VIII antibodies)
o Ongoing or recent (= 3 months) significant GI bleeding or hemoptysis
No requirement for supplemental oxygen (i.e., pulse oximetry < 89% at rest)

Courtesy of ClinicalTrials.gov,

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Mesothelioma
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Treatment
Clinical trials for mesothelioma
IN THIS SECTION
NSC 732517 trial for mesothelioma patients
Eligibility for mesothelioma trial of NSC 732517
Mesothelioma patient profile for NSC 732517 trial
Mesothelioma therapy criteria to test NSC 732517
Mesothelioma Information: NSC
Mesothelioma therapy: NSC
Information on NSC 732517 trial for mesothelioma

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see also:

Eligibility for mesothelioma trial of NSC 732517 Eligibility description for mesothelioma clinical trial of NSC 732517
Patient eligibility to participate in mesothelioma trial of NSC 732517

Mesothelioma patient profile for NSC 732517 trial Patient characteristics for mesothelioma clinical trial of NSC 732517
Mesothelioma patient characteristics in clinical trial of NSC 732517

NSC 732517 trial description for mesothelioma Description of program to treat mesothelioma patients with NSC 732517
Description of study to test NSC 732517 effectiveness on mesothelioma