Clinical Trials for Mesothelioma Patients: Pazopanib

Read about a current clinical trial being conducted to study the effects of Pazopanib for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Rationale and Purpose

Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. This phase II trial is studying the side effects and how well Pazopanib works in treating patients with malignant pleural mesothelioma.

Objectives

Primary

• Determine the effect of Pazopanib hydrochloride on the proportion of patients with malignant pleural mesothelioma who are progression-free at 6 months based on the RECIST criteria.

• Determine the clinical toxicities of this drug in this patient population.

Secondary

• Determine the objective tumor response status in these patients as measured by the RECIST criteria or the modified RECIST criteria.

• Determine the response rate in patients treated with this drug.

• Determine the effect of this drug on overall survival and time to progression in these patients.

• Assess predictive markers of activity of this drug in these patients.

• Assess serologic markers of target inhibition by this drug in these patients.

Outline: This is a multicenter study. Patients receive oral Pazopanib hydrochloride once daily on days 1-21. Treatment repeats every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Blood is collected at baseline and prior to each course of therapy and analyzed for markers of angiogenesis. After completion of study therapy, patients are followed every 3 months.

Courtesy of ClinicalTrials.gov.

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