Clinical Trials for Mesothelioma Patients: Pemetrexed Disodium and Cisplatin

Read about a current clinical trial being conducted to study the effects of pemetrexed disodium and cisplatin for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only. At this time, the study is currently being conducted only in Zurich, Switzerland.

Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma

Rationale: Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.

Purpose: This randomized phase II trial is studying how well giving pemetrexed disodium together with cisplatin followed by surgery with or without radiation therapy works in treating patients with malignant pleural mesothelioma.

Requisite Conditions: Malignant mesothelioma

Interventions; Drugs: cisplatin; pemetrexed disodium. Procedures: adjuvant therapy; chemotherapy; conventional surgery; diagnostic procedure; enzyme inhibitor therapy; laboratory biomarker analysis; neoadjuvant therapy; quality of life assessment; radiation therapy

Courtesy of ClinicalTrials.gov.

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