Clinical Trials for Mesothelioma Patients: Cisplatin, Pemetrexed and Bevacizumab Exclusion Criteria

Read the exclusion criteria for a clinical trial being conducted to study the effects of Cisplatin, Pemetrexed and Bevacizumab for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Exclusion Criteria:
a. General Medical Concerns 5.3.1 Patients must not be pregnant or breast feeding. 5.3.2 No “currently active” second malignancy other than non-melanoma skin cancer. Patients are not considered to have a “currently active” second malignancy if they have completed therapy and have a less than 30% risk of relapse.
5.3.3 No uncontrolled intercurrent illness including but not limited to: active infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social situations that would limit compliance with study requirements.
5.3.4 No HIV positive patients receiving combination anti-retroviral therapy because of possible pharmacokinetic interactions with study medications.
5.3.5 History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab or other agents used in the study.
5.3.6 Inability to interrupt aspirin or other non-steroidal medication for a 5 day period.
c. Bevacizumab-Specific Concerns
Subjects meeting any of the following criteria are ineligible for study entry:
5.3.7 Patients with brain metastases are excluded 5.3.8 History of myocardial infarction or CVA (stroke) within 6 months of study entry.
5.3.9 Evidence of bleeding diathesis or coagulopathy. Patients on therapeutic doses of coumadin are eligible as long as the INR is maintained in the range of 2-3 and there is no evidence of active bleeding.
5.3.10 Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study 5.3.11 Urine 1.0 at screening (see appendix F for instructions on?protein:creatinine ratio calculating the ratio) 5.3.12 Serious, non-healing wound, ulcer, or bone fracture

Courtesy of ClinicalTrials.gov.

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