Clinical Trials for Mesothelioma Patients: Pemetrexed Disodium and Cisplatin Study Criteria

Read the study criteria about a current clinical trial being conducted to study the effects of pemetrexed disodium and cisplatin for patients who have been diagnosed with mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only. At this time, the study is currently being conducted only in Zurich, Switzerland.

Study Phase, Type and Design: Phase II Interventional; Treatment, Randomized, Open Label

Official Title: Neoadjuvant Chemotherapy and Extrapleural Pneumonectomy of Malignant Pleural Mesothelioma (MPM) With or Without Hemithoracic Radiotherapy. A Randomized Multicenter Phase II Trial

Primary Outcome Measures:

• Complete macroscopic resection (part 1) [ Designated as safety issue: No ]

• Loco-regional relapse-free survival (part 2) [ Designated as safety issue: No ]

Secondary Outcome Measures:

• Response to neoadjuvant therapy (part 1) [ Designated as safety issue: No ]

• Adverse drug reaction to neoadjuvant therapy (part 1) [ Designated as safety issue: Yes ]

• Operability (part 1) [ Designated as safety issue: No ]

• Surgical complications (part 1) [ Designated as safety issue: No ]

• Reasons for non-randomization (part 1) [ Designated as safety issue: No ]

• Relapse-free or progression-free survival (part 1) [ Designated as safety issue: No ]

• Adverse reaction to postoperative radiotherapy (part 2) [ Designated as safety issue: Yes ]

• Late toxicity (part 2) [ Designated as safety issue: Yes ]

• Feasibility of postoperative radiotherapy (part 2) [ Designated as safety issue: No ]

• Relapse-free survival (part 2) [ Designated as safety issue: No ]

• Psychological distress (quality of life) (part 2) [ Designated as safety issue: No ]

• Overall survival [ Designated as safety issue: No ]

Courtesy of ClinicalTrials.gov.

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