Clinical Trials for Mesothelioma Patients: Non-Small Cell Lung Cancer, Esophageal Cancer, or Malignant Pleural Mesothelioma Study Objectives

Read about the study objectives for patients with Non-Small Cell Lung Cancer, Esophageal Cancer, or Malignant Pleural Mesothelioma . Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Detailed Description:
Objectives:
Evaluate patients referred to the Thoracic Oncology Section of the Surgery Branch, NCI in order to identify patients who are suitable candidates for clinical research protocols.

Obtain biopsies during staging studies of tumor and adjacent normal tissues as well as serum and urine samples from patients with primary aerodigestive tract malignancies to support preclinical research endeavors in the Thoracic Oncology Section.

Permit standard treatment for patients who are not eligible for investigational therapy on a current Thoracic Oncology protocol, but who present a novel and unique clinical training opportunity, or who manifest a clinical condition that requires immediate intervention to prevent compromise to the patient's well-being.

Outline:
This is a prospective study. Patients undergo bronchoscopy and/or bronchoalveolar lavage (BAL). Tumor tissue and normal tissue are collected via endoscopy, fine-needle aspiration, core-needle techniques, or single-port site thoracoscopic methods. Biopsies and BAL fluids are examined for gene expression and DNA methylation analysis. Blood and urine are also collected.

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