Clinical Trials for Mesothelioma Patients—Vaccine Therapy and GM-CSF: Disease Characteristics Criteria
Read about the concurrent therapy for a current clinical trial to test vaccine therapy GM-CSF on patients with the disease mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.
Disease Characteristics Criteria:
· Cytologically or histologically confirmed diagnosis of 1 of the following:
o Acute myeloid leukemia, meeting the following criteria:
- Documented Wilms tumor-1 (WT-1)-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease with real-time quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR)
- Completed induction chemotherapy, achieved clinical remission, and completed postremission therapy OR achieved clinical remission and have no plans for further postremission chemotherapy (= 65 years of age)
o Myelodysplastic syndromes, meeting the following criteria:
- Documented WT-1-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease by RQ-PCR
- International Prognostic Scoring System (IPSS) score of = Int-2
- Not a candidate for cytotoxic chemotherapy
o Non-small cell lung cancer, meeting the following criteria:
- Positive tumor staining for WT-1 in > 10% of cells
- Stage III or IV disease
- Completed chemotherapy, surgery, and/or radiotherapy
o Mesothelioma, meeting the following criteria:
- Positive tumor staining for WT-1 in > 10% of cells
- Unresectable or relapsed disease
- Chemo-naive or received 1 prior chemotherapy regimen
Courtesy of ClinicalTrials.gov, a service of the U.S. National Institutes of Health
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Objectives of clinical study to test vaccine GM-CSF on mesothelioma