Clinical Trials for Mesothelioma Patients—Vaccine Therapy and GM-CSF: Disease Characteristics Criteria

Read about the concurrent therapy for a current clinical trial to test vaccine therapy GM-CSF on patients with the disease mesothelioma. Please note: this information is provided by Weitz & Luxenberg for informational purposes only.

Disease Characteristics Criteria:

·         Cytologically or histologically confirmed diagnosis of 1 of the following:

o        Acute myeloid leukemia, meeting the following criteria:

• Documented Wilms tumor-1 (WT-1)-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease with real-time quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR)
• Completed induction chemotherapy, achieved clinical remission, and completed postremission therapy OR achieved clinical remission and have no plans for further postremission chemotherapy (= 65 years of age)

o        Myelodysplastic syndromes, meeting the following criteria:

• Documented WT-1-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease by RQ-PCR
• International Prognostic Scoring System (IPSS) score of = Int-2
• Not a candidate for cytotoxic chemotherapy

o        Non-small cell lung cancer, meeting the following criteria:

• Positive tumor staining for WT-1 in > 10% of cells
• Stage III or IV disease
• Completed chemotherapy, surgery, and/or radiotherapy

o        Mesothelioma, meeting the following criteria:

• Positive tumor staining for WT-1 in > 10% of cells
• Unresectable or relapsed disease
• Chemo-naive or received 1 prior chemotherapy regimen

Courtesy of ClinicalTrials.gov, a service of the U.S. National Institutes of Health

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