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Chemistry & Pharmacology

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All You Need to Know About Paxil CR Chemistry & Pharmacology

Listed here is the chemistry & pharmacology of the anti-depressant Paxil CR.

Paroxetine is chemically identified as (Immediate-Release Tablets / Oral Suspension:) (-)-trans-4R-(4-fluorophenyl)-3S-[(3,4-methylenedioxyphenoxy) methyl]piperidine hydrochloride hemihydrate, or (Controlled-Release Tablets:) (-)-(3S,4R)-4-[(p-fluorophenyl)-3-[(3,4-methylenedioxy)phenoxy]methyl] piperidine hydrochloride hemihydrate. Its empirical formula is C19H20FNO3, with a molecular weight of 374.8 (329.3703 as free base).

Paroxetine hydrochloride is an odorless, whitish powder, with a melting point range of 120° to 138°C and a solubility of 5.4 mg/mL in water.

Paxil Pharmacology

Paroxetine is a strong and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant effects.

Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the tricyclic or tetracyclic antidepressants. In receptor binding studies, paroxetine did not exhibit significant affinity for the adrenergic (alpha(1), alpha(2), beta), dopaminergic, serotonergic (5HT(1), 5HT(2)), or histaminergic receptors of rat brain membrane. A weak affinity for the muscarinic acetylcholine receptor was apparent. The predominant metabolites of paroxetine are inactive as 5-HT reuptake inhibitors.

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see also:

Chemistry & Pharmacology Get all the Facts about Paxil CR Chemistry & Pharmacology
The science behind Paxil CR - See its Chemistry & Pharmacology

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