Trasylol Side Effect - Stroke
A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted. In brain tissue, a reduction of blood flow, ischemia, leads to an ischemic cascade that can damage or kill brain cells. Death of brain tissue can lead to loss of the function controlled by that tissue. Thus stroke is the third leading cause of death and leading cause of adult disability in the US and industrialized European nations (Jauch, 2005), and is a medical emergency. To underscore the seriousness of stroke, in recent years the term brain attack has become increasingly popular, in relation to the established term "heart attack" used for myocardial infarction.
Ischemic stroke
Stroke is classified by its cause into two main types: ischemic and hemorrhagic. In ischemic stroke, which occurs in approximately 85-90% of strokes, a blood vessel becomes occluded and the blood supply to part of the brain is totally or partially blocked. Ischemic stroke is commonly divided into thrombotic and embolic (Stroke Center, 2005). Rarer types of stroke can occur (see below)
Embolic stroke
In embolic stroke, an embolus, or a travelling particle in a blood vessel, flows with the bloodstream into progressively smaller arteries until it becomes lodged, inhibiting passage of blood. An embolus is most frequently a blood clot, but it can also be a plaque broken off from an atherosclerotic blood vessel or a number of other things including fat, air, and even cancerous cells (Perry and Miller 1961). An embolism may also be formed when the heart pumps ineffectively, allowing the blood to pool and coagulate, as occurs in certain heart arrhythmia such as atrial fibrillation (NINDS 1999).
Thrombotic stroke
In thrombotic stroke, the clot does not travel; it builds up and finally occludes the artery where it forms. When there is a tear in an artery wall, platelets and clotting factors in the blood are drawn to the area and aggregate there, forming a clot. They send out chemicals that can trigger a clotting cascade. Arterial clots usually form around atherosclerotic plaques (NINDS 1999). Since occlusion takes longer, onset of thrombotic strokes is slower.
Blood flow can also be restricted in a condition called arterial stenosis, in which plaques build up on the artery wall, causing the vessel to become narrow and stiff (NINDS 1999).
see also:
Heart Attack
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